Morpholine → HCID 23144356, compound

HRID 1361855Notes

Reaction equation

HRID 1361855 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[S:12][C:13]([C:21]([CH:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[O:22])=[C:14]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)=[O:9])=[CH:4][N:3]=1.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>O1CCOCC1>[O:17]1[CH:18]=[CH:19][CH:20]=[C:16]1[C:14]1[N:15]=[C:11]([NH:10][C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[N:3][CH:4]=2)=[O:9])[S:12][C:13]=1[C:21]([CH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1)=[O:22]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 23144385HCID 23144385, compound

Product 1

HCID 23144356HCID 23144356, compoundYield 40,585.801%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

Compound 502 (100 mg, 0.239 mmol) was suspended in 1,4-dioxane (1 mL), and morpholine (0.063 mL, 0.72 mmol) was added thereto, followed by stirring overnight at 100° C. The reaction mixture was concentrated under reduced pressure, and the resulting residue was reslurried with ethanol to afford the entitled Compound 503 (109 mg, 97 mmol) as a pale brown solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ffb805a2094243ac822b8fa11e55f26d
Source dataset
uspto-grants-2011_02
Patent number
US07880013B2

Reaction notes

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