HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1361858Generated: October 25, 2026
Hydroxyamine hydrochloride → N-[4-(2-Furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]-5-(hydroxyimino)furan-2-carboxamide
https://huagongshe.com/reaction/1361858
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 5-Formyl-N-[4-(2-furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]furan-2-carboxamide | HCID 23144705 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[4-(2-Furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]-5-(hydroxyimino)furan-2-carboxamide | HCID 86612469 | 86.3% |
Reaction Steps
Compound 513 (2.40 g, 6.00 mmol) was suspended in ethanol (24 mL), and hydroxylamine hydrochloride (438 mg, 6.30 mmol) was added thereto, followed by stirring at 60° C. for 1 hour. The precipitated solid was collected by filtration to afford the entitled Compound 514 (2.09 g, 84%) as a pale brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07880013B2 |
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| Source dataset | uspto-grants-2011_02 |
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| ORD ID | ord-6a4b911dbbcc4e68b251c312513656af |
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| Source note | uspto-grants-2011_02 |
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