Hydroxyamine hydrochloride → N-[4-(2-Furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]-5-(hydroxyimino)furan-2-carboxamide

HRID 1361858Notes

Reaction equation

C([C:3]1[O:7][C:6]([C:8]([NH:10][C:11]2[S:12][C:13]([C:21]([CH:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[O:22])=[C:14]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)=[O:9])=[CH:5][CH:4]=1)=O.Cl.[NH2:30][OH:31]>C(O)C>[O:17]1[CH:18]=[CH:19][CH:20]=[C:16]1[C:14]1[N:15]=[C:11]([NH:10][C:8]([CH:6]2[CH:5]=[CH:4][C:3](=[N:30][OH:31])[O:7]2)=[O:9])[S:12][C:13]=1[C:21]([CH:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1)=[O:22]

Participants

Conditions

Temperature: 60 °C

Procedure

Compound 513 (2.40 g, 6.00 mmol) was suspended in ethanol (24 mL), and hydroxylamine hydrochloride (438 mg, 6.30 mmol) was added thereto, followed by stirring at 60° C. for 1 hour. The precipitated solid was collected by filtration to afford the entitled Compound 514 (2.09 g, 84%) as a pale brown solid.

Workup

filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record: ord-6a4b911dbbcc4e68b251c312513656af
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07880013B2

Reaction notes

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