反应详情

To a stirred solution of tert-butyl (E)-3-(2-oxo-2,3-dihydro-1H-indol-5-yl)acrylate (0.80 g, 3.1 mmole) in CH2Cl2 (50 mL) at RT was added trifluoroacetic acid (20 mL). After 1 hr the reaction solution was concentrated and the residue was dried under vacuum. An HCl solution (20 mL, 4 M in dioxane) was added and the mixture was concentrated under vacuum. The remaining solid was triturated with diethyl ether and filtered giving the title compound (0.74 g, 33%) as a white solid: MS (ES) m/e 205 (M+H−HCl)+.

1. concentrationAfter 1 hr the reaction solution was concentrated
2. customthe residue was dried under vacuum
3. additionAn HCl solution (20 mL, 4 M in dioxane) was added
4. concentrationthe mixture was concentrated under vacuum
5. customThe remaining solid was triturated with diethyl ether
6. filtrationfiltered