Hydroxyamine hydrochloride → 6,7-dihydro-8(5H)-quinolinone oxime

HRID 1361967Notes

Reaction equation

HRID 1361967 reaction equation
[N:1]1[C:10]2[C:9](=O)[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl.[NH2:13][OH:14]>>[N:1]1[C:10]2[C:9](=[N:13][OH:14])[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 117447776,7-Dihydro-5H-quinoline-8-one

Product 1

HCID 1357421856,7-dihydro-8(5H)-quinolinone oximeYield 96%

Procedure

According to the reported procedure (J. Het. Chem. 1978, 15, 249-251), 6,7-dihydro-5H-quinolin-8-one was reacted with hydroxylamine hydrochloride to afford the title compound (2.40 g, 96%) as a white solid after drying in vacuo: MS (ES) m/e 163 (M+H)+.

Sources & evidence

ORD record
ord-f821da475dd845eb9a8ffc1a83732bb3
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

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