反应详情

A solution of 50% TFA in CH2Cl2 (75 mL) was added to tert-butyl (E)-3-[6-[N-(methoxycarbonylmethyl)amino]pyridin-3-yl]acrylate (5.20 g, 17.8 mmole). The reaction was stirred at room temperature for 45 min then was concentrated under vacuum. The residue was taken up in 4.0 N HCl in dioxane (75 mL), stirred for 5 min, then concentrated to dryness under vacuum. The remaining solid was triturated with 1:1 Et2O/petroleum ether, filtered and dried under vacuum to give the title compound (4.87 g, 100%) as a white solid: MS (ES) m/e 237.2 (M+H)+.

1. concentrationthen was concentrated under vacuum
2. stirringstirred for 5 min
3. concentrationconcentrated to dryness under vacuum
4. customThe remaining solid was triturated with 1:1 Et2O/petroleum ether
5. filtrationfiltered
6. customdried under vacuum