HCID 66961388, compound → HCID 12647251, compound

HRID 1362624Notes

Reaction equation

HRID 1362624 reaction equation
[F:1][CH2:2][C@H:3]([N:11]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>O.NN.C(O)C>[F:1][CH2:2][C@H:3]([NH2:11])[CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 1

HCID 66961388HCID 66961388, compound

Product 1

HCID 12647251HCID 12647251, compoundYield 21.3%

Reagents, catalysts & solvents 2

HCID 24654Hydrazine hydrate (1:1)CatalystHCID 702EthanolSolvent

Procedure

A mixture of (R)-2-(1-fluoromethyl-2-phenylethyl)isoindol-1,3-dione (52 mg) and hydrazine hydrate (two drops) and ethanol (1 mL) was heated to reflux for 2 hours. The reaction solution was allowed to be cooled to room temperature, and the deposited crystal was separated by filtration and concentrated under reduced pressure. The residue was purified by LC-MS and 6.0 mg of the title compound was obtained.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 2 hours
  3. customthe deposited crystal was separated by filtration
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by LC-MS

Sources & evidence

ORD record
ord-6c8db4470de84dadbea157e858ea4a5f
Source dataset
uspto-grants-2011_02
Patent number
US07880009B2

Reaction notes

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