Trifluoroacetic acid → HCID 66960177, compound

HRID 1362694Notes

Reaction equation

HRID 1362694 reaction equation
FC(F)(F)C(O)=O.C([O:12][C:13](=[O:34])[C:14](=[CH:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH:30]=[CH:29][N:28]=[C:27]2[Cl:31])=[C:22]([O:32][CH3:33])[CH:21]=1)[CH2:15][CH2:16][CH2:17][Cl:18])(C)(C)C>>[Cl:18][CH2:17][CH2:16][CH2:15]/[C:14](=[CH:19]\[C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH:30]=[CH:29][N:28]=[C:27]2[Cl:31])=[C:22]([O:32][CH3:33])[CH:21]=1)/[C:13]([OH:34])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66960176HCID 66960176, compound

Product 1

HCID 66960177HCID 66960177, compoundYield 84.9%

Procedure

A trifluoroacetic acid (15 mL) solution of 5-chloro-2-(4-(2-chloro-1H-imidazol-1-yl)-3-methoxybenzylidene)valeric acid tert-butyl ester (1.35 g) was agitated under ice-cooling. The reaction solution was concentrated under reduced pressure after 2 hours. When the residue was purified in LC-MS, 0.99 g of the title compound was obtained. The physical properties of the compound are as follows.

Workup

  1. temperaturecooling
  2. concentrationThe reaction solution was concentrated under reduced pressure after 2 hours
  3. customWhen the residue was purified in LC-MS

Sources & evidence

ORD record
ord-157151a28d094b5fb3f01e2d1fa262a7
Source dataset
uspto-grants-2011_02
Patent number
US07880009B2

Reaction notes

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