Hydrogen chloride-ethyl acetate → HCID 66961203, compound

HRID 1362763Notes

Reaction equation

HRID 1362763 reaction equation
C(OC(=O)[NH:7][C:8]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)([CH3:11])[CH2:9][OH:10])(C)(C)C.C(OC(=O)C)C.[ClH:26]>C(OCC)(=O)C>[ClH:26].[NH2:7][C:8]([C:12]1[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=1)([CH3:11])[CH2:9][OH:10]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86602495HCID 86602495, compound

Product 1

HCID 66961203HCID 66961203, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To an ethyl acetate (1 mL) solution of (1-(4-fluorophenyl)-2-hydroxy-1-methylethyl)carbamic acid tertiary butyl ester (252 mg), 4 N hydrochloric acid ethyl acetate solution (3 mL) was added, and the reaction solution was agitated at room temperature for 3 hours. The reaction solution was concentrated under reduced pressure to obtain 192 mg of the title compound. The physical properties of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-fd5592620c6c4d3682dab8e3e83def26
Source dataset
uspto-grants-2011_02
Patent number
US07880009B2

Reaction notes

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