Ammonia → 2-Chloro-4-methyl-1,3-thiazole-5-sulfonamide

HRID 1362779Notes

Reaction equation

HRID 1362779 reaction equation
[NH3:1].[Cl:2][C:3]1[S:4][C:5]([S:9](Cl)(=[O:11])=[O:10])=[C:6]([CH3:8])[N:7]=1>O1CCCC1>[Cl:2][C:3]1[S:4][C:5]([S:9]([NH2:1])(=[O:11])=[O:10])=[C:6]([CH3:8])[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 120942502-Chloro-4-methyl-1,3-thiazole-5-sulfonyl chloride

Product 1

HCID 120942512-Chloro-4-methyl-1,3-thiazole-5-sulfonamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

117.7 g (1.8 mol) of 26% strength aqueous ammonia solution are added dropwise to a solution of 208 g (95% pure, 0.9 mol) of 2-chloro-4-methyl-1,3-thiazole-5-sulfonyl chloride in 1000 ml of tetrahydrofuran at −10° C. The reaction mixture is left to stirr without further cooling for 2 h and is then concentrated in a rotary evaporator. The crude product is employed without further purification in the next stage.

Workup

  1. waitThe reaction mixture is left
  2. temperaturewithout further cooling for 2 h
  3. concentrationis then concentrated in a rotary evaporator
  4. customThe crude product is employed without further purification in the next stage

Sources & evidence

ORD record
ord-a10768a1b7d747e0a74c74a15acab8ab
Source dataset
uspto-grants-2011_02
Patent number
US07883713B2

Reaction notes

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