Methylamine → 4-Methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide

Participants

Reaction Conditions

Reaction Steps

144 g (0.576 mol) of 2-chloro-4-methyl-1,3-thiazole-5-sulfonamide are introduced at room temperature into 600 ml of acetonitrile, and 147 g (1.9 mol) of 40% strength aqueous methylamine solution are metered in at room temperature. The reaction mixture is stirred at 50° C. for 6 h and then concentrated in a rotary evaporator. The residue is mixed with water, filtered with suction and dried.

Provenance & Evidence