Methylamine → 4-Methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide

HRID 1362780Notes

Reaction equation

HRID 1362780 reaction equation
Cl[C:2]1[S:3][C:4]([S:8]([NH2:11])(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1.[CH3:12][NH2:13]>C(#N)C>[CH3:7][C:5]1[N:6]=[C:2]([NH:13][CH3:12])[S:3][C:4]=1[S:8]([NH2:11])(=[O:10])=[O:9]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 120942512-Chloro-4-methyl-1,3-thiazole-5-sulfonamide

Product 1

HCID 112757814-Methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
50 °C

Procedure

144 g (0.576 mol) of 2-chloro-4-methyl-1,3-thiazole-5-sulfonamide are introduced at room temperature into 600 ml of acetonitrile, and 147 g (1.9 mol) of 40% strength aqueous methylamine solution are metered in at room temperature. The reaction mixture is stirred at 50° C. for 6 h and then concentrated in a rotary evaporator. The residue is mixed with water, filtered with suction and dried.

Workup

  1. customare metered in at room temperature
  2. concentrationconcentrated in a rotary evaporator
  3. additionThe residue is mixed with water
  4. filtrationfiltered with suction
  5. customdried

Sources & evidence

ORD record
ord-97e1b04c959343198baf6b724376f40a
Source dataset
uspto-grants-2011_02
Patent number
US07883713B2

Reaction notes

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