Tetrahydrofuran → (5-Bromo-2-fluorophenyl)(6-chloro-2-fluoro-3-(methoxymethoxy)pyridin-4-yl)methanol
Reaction equation
[Br:18][c:19]1[cH:20][cH:21][c:22]([F:27])[c:23]([CH:24]=[O:25])[cH:26]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[Cl:6][c:7]1[cH:8][cH:9][c:10]([O:14][CH2:15][O:16][CH3:17])[c:11]([F:13])[n:12]1>>[Cl:6][c:7]1[cH:8][c:9]([CH:24]([c:23]2[c:22]([F:27])[cH:21][cH:20][c:19]([Br:18])[cH:26]2)[OH:25])[c:10]([O:14][CH2:15][O:16][CH3:17])[c:11]([F:13])[n:12]1Participants
5
Sources & evidence
- ORD record
- ord-481b65a79ec549099f79ed2e145568a2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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