HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Butyl-8-[(3R)-3-pyrrolidinyloxy]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-dimethylethyl (3R)-3-[(6-butyl-8-quinolinyl)oxy]-1-pyrrolidinecarboxylate | HCID 66921936 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Butyl-8-[(3R)-3-pyrrolidinyloxy]quinoline | HCID 66921730 | — |
Reaction Steps
This was prepared in an analogous manner to Intermediate 4, using 1,1-dimethylethyl (3R)-3-[(6-butyl-8-quinolinyl)oxy]-1-pyrrolidinecarboxylate (for example, as prepared for Intermediate 9) and 4 M hydrogen chloride in 1,4-dioxane instead of trifluoroacetic acid for 45 min. LCMS RT=2.46 min, ES+ve m/z 271 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884114B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-1e8a367010784ed7bf6362ff9e20f5ee |
| Source note | uspto-grants-2011_02 |