HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 4-Chloro-N-propyl-1-butanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | 4-Chlorobutane-1-sulphonyl chloride | HCID 74212 | — |
| Product | 4-Chloro-N-propyl-1-butanesulfonamide | HCID 65754869 | 88% |
Reaction Steps
This was prepared in an analogous manner to that disclosed for Intermediate 41, using n-propylamine (commercially available, for example, from Aldrich) instead of t-butylamine, and 4-chloro-1-butanesulfonyl chloride (prepared according to White, E. H.; Lim, H. M. J. Org. Chem. 52, 1987, 11, 2162-2166) instead of 3-chloropropane sulfonyl chloride. Yield 88%. LCMS RT=2.54 min, ES+ve m/z 214 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884114B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-72884ef13e5c46468453f79f2a95c53b |
| Source note | uspto-grants-2011_02 |