Tert-Butylamine → 4-Chloro-N-propyl-1-butanesulfonamide

HRID 1363018Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1363018
[CH2:1]([NH2:4])[CH2:2][CH3:3].C(N)(C)(C)C.[Cl:10][CH2:11][CH2:12][CH2:13][CH2:14][S:15](Cl)(=[O:17])=[O:16]>>[Cl:10][CH2:11][CH2:12][CH2:13][CH2:14][S:15]([NH:4][CH2:1][CH2:2][CH3:3])(=[O:17])=[O:16]

Komponenten

4

Edukt 3

HCID 6385Tert-ButylamineHCID 7852PropylamineHCID 742124-Chlorobutane-1-sulphonyl chloride

Produkt 1

HCID 657548694-Chloro-N-propyl-1-butanesulfonamideAusbeute 88 %

Versuchsvorschrift

This was prepared in an analogous manner to that disclosed for Intermediate 41, using n-propylamine (commercially available, for example, from Aldrich) instead of t-butylamine, and 4-chloro-1-butanesulfonyl chloride (prepared according to White, E. H.; Lim, H. M. J. Org. Chem. 52, 1987, 11, 2162-2166) instead of 3-chloropropane sulfonyl chloride. Yield 88%. LCMS RT=2.54 min, ES+ve m/z 214 (M+H)+.

Aufarbeitung

  1. customThis was prepared in an analogous manner to

Quellen und Nachweise

ORD-Eintrag
ord-72884ef13e5c46468453f79f2a95c53b
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07884114B2

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