HCID 59778184, compound → HCID 59983182, compound

HRID 1363099Notes

Reaction equation

HRID 1363099 reaction equation
[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[CH:15][CH:16]=2)[CH2:11][C:10]([NH:26]C(=O)OCC2C=CC=CC=2)([CH3:25])[C:9]1=[O:37])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)=[CH:15][CH:16]=2)[CH2:11][C:10]([CH3:25])([NH2:26])[C:9]1=[O:37])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 59778184HCID 59778184, compound

Product 1

HCID 59983182HCID 59983182, compoundYield 94.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 148F (340 mg, 0.69 mmol) in MeOH (8 mL) was added 5% palladium on carbon (200 mg). The resulting suspension was hydrogenated under hydrogen balloon for 1 h., then filtered. The filtrate was concentrated to give title compound (235 mg, 94% yield) as an off-white foam.

Workup

  1. customfor 1 h.
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-6adab01b1eea448abd7c3172f50401b9
Source dataset
uspto-grants-2011_02
Patent number
US07884113B2

Reaction notes

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