Benzaldehyde → 3-Amino-1-benzyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile

HRID 1363110Notes

Reaction equation

HRID 1363110 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]#[N:19])[CH:15]=2)[NH:10][CH2:9]1)(C)(C)C.[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[NH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]#[N:19])[CH:15]=2)[N:10]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 240BenzaldehydeHCID 66692977tert-Butyl (6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)carbamate

Product 1

HCID 667576433-Amino-1-benzyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile

Procedure

157A was prepared from 1C and benzaldehyde by procedures analogous to those described in Example 22A, followed by removal of N-Boc protecting group according to the procedures described in Example 22B.

Workup

  1. customfollowed by removal of N-Boc protecting group

Sources & evidence

ORD record
ord-77b5a933623b4472b55014a9ff1d7322
Source dataset
uspto-grants-2011_02
Patent number
US07884113B2

Reaction notes

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