反应详情

Under a N2 atmosphere, 4-(phenylethynyl)thiophene-2-carbaldehyde (386 mg, 1.8 mmol) was dissolved EtOAc (6 mL), and palladium on carbon (Pd/C) (44 mg) was added. The flask was evacuated and flushed with H2 (3×). The reaction stirred at rt overnight with a balloon of H2. The mixture was filtered through a plug of Celite® and the filtrate was concentrated to give 4-phenethylthiophene-2-carbaldehyde (373 mg, 95%). 1H NMR (400 MHz, CDCl3) δ (ppm): 9.87 (d, 1H), 7.56 (d, 1H), 7.33 (m, 1H), 7.29 (m, 2H), 7.23 (m, 1H), 7.16 (m, 2H), 2.97 (m, 4H).

1. additionwas added
2. customThe flask was evacuated
3. customflushed with H2 (3×)
4. filtrationThe mixture was filtered through a plug of Celite®
5. concentrationthe filtrate was concentrated