Potassium Carbonate → HCID 59648687, compound

HRID 1363309Notes

Reaction equation

HRID 1363309 reaction equation
C([O-])([O-])=O.[K+:5].[K+].[CH3:7][N:8]1[C:15]2[CH:14]=[C:13]([C:16]([OH:18])=[O:17])[NH:12][C:11]=2[CH:10]=[CH:9]1>O.CO>[K+:5].[CH3:7][N:8]1[C:15]2[CH:14]=[C:13]([C:16]([O-:18])=[O:17])[NH:12][C:11]=2[CH:10]=[CH:9]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 510000431007386-48-2

Product 1

HCID 59648687HCID 59648687, compoundYield 182.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

To a suspension of K2CO3 (0.110 g, 0.798 mmol) in H2O (0.4 mL) and MeOH (2 mL) was added a solution of 4-methyl-1,4-dihydropyrrolo[3,2-b]pyrrole-2-carboxylic acid 12 (262 mg, 1.60 mmol) in MeOH (2 mL). The solution was stirred for 20 min and was then concentrated in vacuo to give potassium-4-methyl-1,4-dihydro-pyrrolo[3,2-b]pyrrole-2-carboxylate 12a as a grey solid (294 mg, 91%). 1H NMR (400 MHz, (CD3)2SO) δ (ppm) 9.80 (s, 1H) 6.58 (d, J=2.8 Hz, 1H) 6.10 (s, 1H) 5.70 (dd, J=2.8, 0.8 Hz, 1H) 3.55-3.57 (m, 3H).

Workup

  1. concentrationwas then concentrated in vacuo

Sources & evidence

ORD record
ord-64e5a0fba3bb4535945a50efa5a3ee9e
Source dataset
uspto-grants-2011_02
Patent number
US07884124B2

Reaction notes

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