Methanesulfonic Acid → HCID 87209271, compound

HRID 1363345Notes

Reaction equation

HRID 1363345 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[C:11]([Cl:13])[C:10]([F:14])=[CH:9][C:8]=1[C:15]1[O:16][C:17]2[C:22]([C:23](=[O:25])[CH:24]=1)=[C:21]([OH:26])[CH:20]=[C:19]([OH:27])[C:18]=2[C@@H:28]1[CH2:32][CH2:31][N:30]([CH3:33])[C@H:29]1[CH2:34][OH:35]>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[C:11]([Cl:13])[C:10]([F:14])=[CH:9][C:8]=1[C:15]1[O:16][C:17]2[C:22]([C:23](=[O:25])[CH:24]=1)=[C:21]([OH:26])[CH:20]=[C:19]([OH:27])[C:18]=2[C@@H:28]1[CH2:32][CH2:31][N:30]([CH3:33])[C@H:29]1[CH2:34][OH:35]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 66933856HCID 66933856, compound

Product 1

HCID 87209271HCID 87209271, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

Methanesulfonic acid (0.012 g, 0.125 mmol) was added to the suspension of compound of example 47 (0.05 g, 0.11 mmol) in methanol (2 mL). It was stirred for 5 min. at 25° C. to obtain clear solution. The solvent was removed under reduced pressure to obtain residue. The residue was washed twice with dry ether (2×5 mL) and dried under high vacuum (0.1 mm) to obtain the title compound.

Workup

  1. customto obtain clear solution
  2. customThe solvent was removed under reduced pressure
  3. customto obtain residue
  4. washThe residue was washed twice with dry ether (2×5 mL)
  5. customdried under high vacuum (0.1 mm)

Sources & evidence

ORD record
ord-6f9b60d05bd74c6dba78813d2a07ab43
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

Loading…