2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) → HCID 66933880, compound

HRID 1363346Notes

Reaction equation

HRID 1363346 reaction equation
O.[C:2]([OH:14])(=[O:13])[CH2:3][C:4]([CH2:9][C:10]([OH:12])=[O:11])([C:6]([OH:8])=[O:7])[OH:5].[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[C:19]([F:23])=[CH:18][C:17]=1[C:24]1[O:25][C:26]2[C:31]([C:32](=[O:34])[CH:33]=1)=[C:30]([OH:35])[CH:29]=[C:28]([OH:36])[C:27]=2[C@@H:37]1[CH2:41][CH2:40][N:39]([CH3:42])[C@H:38]1[CH2:43][OH:44]>CO>[C:2]([OH:14])(=[O:13])[CH2:3][C:4]([CH2:9][C:10]([OH:12])=[O:11])([C:6]([OH:8])=[O:7])[OH:5].[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[C:19]([F:23])=[CH:18][C:17]=1[C:24]1[O:25][C:26]2[C:31]([C:32](=[O:34])[CH:33]=1)=[C:30]([OH:35])[CH:29]=[C:28]([OH:36])[C:27]=2[C@@H:37]1[CH2:41][CH2:40][N:39]([CH3:42])[C@H:38]1[CH2:43][OH:44]

Participants

4

Reactant 2

HCID 222302-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)HCID 66933856HCID 66933856, compound

Product 1

HCID 66933880HCID 66933880, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
52.5 °C

Procedure

Citric acid monohydrate (0.023 g, 0.11 mmol) was added to the suspension of compound of example 47 (0.05 g, 0.11 mmol) in methanol (2 mL). It was stirred for 10 min. at 50-55° C. The reaction mixture was concentrated and solid was dried to obtain the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customsolid was dried

Sources & evidence

ORD record
ord-a40b1936d74f407684fc8e02a3e988f0
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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