Acetic Acid → HCID 66933986, compound

HRID 1363349Notes

Reaction equation

HRID 1363349 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([F:13])=[CH:8][C:7]=1[C:14]1[O:15][C:16]2[C:21]([C:22](=[O:24])[CH:23]=1)=[C:20]([OH:25])[CH:19]=[C:18]([OH:26])[C:17]=2[C@@H:27]1[CH2:31][CH2:30][N:29]([CH3:32])[C@H:28]1[CH2:33][OH:34]>CO>[C:1]([OH:4])(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([F:13])=[CH:8][C:7]=1[C:14]1[O:15][C:16]2[C:21]([C:22](=[O:24])[CH:23]=1)=[C:20]([OH:25])[CH:19]=[C:18]([OH:26])[C:17]=2[C@@H:27]1[CH2:31][CH2:30][N:29]([CH3:32])[C@H:28]1[CH2:33][OH:34]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 66933856HCID 66933856, compound

Product 1

HCID 66933986HCID 66933986, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
52.5 °C

Procedure

Acetic acid (0.0068 g, 0.11 mmol) was added to the suspension of compound of example 47 (0.05 g, 0.11 mmol) in methanol (2 mL). It was stirred for 5 min. at 50-55° C. to get clear solution. The reaction mixture was concentrated and solid was dried to obtain the title compound.

Workup

  1. customto get clear solution
  2. concentrationThe reaction mixture was concentrated
  3. customsolid was dried

Sources & evidence

ORD record
ord-e71afc028d7b44e28e58673fcd4249af
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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