Sulfuric Acid → HCID 66933873, compound

HRID 1363350Notes

Reaction equation

HRID 1363350 reaction equation
[OH:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[C:11]([Cl:13])[C:10]([F:14])=[CH:9][C:8]=1[C:15]1[O:16][C:17]2[C:22]([C:23](=[O:25])[CH:24]=1)=[C:21]([OH:26])[CH:20]=[C:19]([OH:27])[C:18]=2[C@@H:28]1[CH2:32][CH2:31][N:30]([CH3:33])[C@H:29]1[CH2:34][OH:35]>CO>[S:2]([OH:5])([OH:4])(=[O:3])=[O:1].[Cl:6][C:7]1[CH:12]=[C:11]([Cl:13])[C:10]([F:14])=[CH:9][C:8]=1[C:15]1[O:16][C:17]2[C:22]([C:23](=[O:25])[CH:24]=1)=[C:21]([OH:26])[CH:20]=[C:19]([OH:27])[C:18]=2[C@@H:28]1[CH2:32][CH2:31][N:30]([CH3:33])[C@H:29]1[CH2:34][OH:35]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 66933856HCID 66933856, compound

Product 1

HCID 66933873HCID 66933873, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
52.5 °C

Procedure

H2SO4 solution (55 μL, 5% methanolic solution, 0.055 mmol) was added to the suspension of compound of example 47 (0.025 g, 0.055 mmol) in methanol (2 mL). It was stirred for 5 min at 50-55° C. The reaction mixture was concentrated and solid was dried to obtain the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customsolid was dried

Sources & evidence

ORD record
ord-e933ea34ed854311956724b9d5f238bf
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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