Nitric Acid → HCID 66933957, compound

HRID 1363351Notes

Reaction equation

HRID 1363351 reaction equation
[N+:1]([O-:4])([OH:3])=[O:2].[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([F:13])=[CH:8][C:7]=1[C:14]1[O:15][C:16]2[C:21]([C:22](=[O:24])[CH:23]=1)=[C:20]([OH:25])[CH:19]=[C:18]([OH:26])[C:17]=2[C@@H:27]1[CH2:31][CH2:30][N:29]([CH3:32])[C@H:28]1[CH2:33][OH:34]>CO>[N+:1]([O-:4])([OH:3])=[O:2].[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([F:13])=[CH:8][C:7]=1[C:14]1[O:15][C:16]2[C:21]([C:22](=[O:24])[CH:23]=1)=[C:20]([OH:25])[CH:19]=[C:18]([OH:26])[C:17]=2[C@@H:27]1[CH2:31][CH2:30][N:29]([CH3:32])[C@H:28]1[CH2:33][OH:34]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 66933856HCID 66933856, compound

Product 1

HCID 66933957HCID 66933957, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
52.5 °C

Procedure

HNO3 solution (55 μL, 6.9% methanolic solution, 0.055 mmol) was added to the suspension of compound of example 47 (0.025 g, 0.055 mmol) in methanol (2 mL). It was stirred for 5 min. at 50-55° C. to get clear solution. The reaction mixture was concentrated and solid was dried to obtain the title compound.

Workup

  1. customto get clear solution
  2. concentrationThe reaction mixture was concentrated
  3. customsolid was dried

Sources & evidence

ORD record
ord-b64c62d7592c4a09b48bdcd616028cea
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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