反应详情

温度

100 °C

Anhydrous potassium carbonate was added to a solution of 4-methoxyaniline (1.2 g, 9.8 mmol) in ethanol (10 mL) followed by a dropwise addition of a solution of compound of example 116 (2.77 g, 9.8 mmol) in water (3.0 mL). The reaction mixture was heated at 100° C. for 1 h., allowed to cool to room temperature, poured into ice water (100 mL) and extracted using EtOAc (3×50 mL). The organic extract was washed with water, dried (anhydrous Na2SO4) and concentrated to get the title compound.

1. temperatureto cool to room temperature
2. extractionextracted
3. extractionThe organic extract
4. washwas washed with water
5. dry with materialdried (anhydrous Na2SO4)
6. concentrationconcentrated