反应详情

温度

62.5 °C

To a solution of compound of example 163 (2.8 g, 15 mmol) in dry dioxane (50 mL) was added NaH (50%, 1.44 g, 30 mmol) and dimethyl sulfate (3.78 g, 30 mmol). It was stirred at 60-65° C. for 1 h. It was poured into ice water and extracted with EtOAc (2×100 mL). The organic extract was washed with brine, dried (anhydrous Na2SO4) and concentrated to obtain the title compound.

1. extractionextracted with EtOAc (2×100 mL)
2. extractionThe organic extract
3. washwas washed with brine
4. dry with materialdried (anhydrous Na2SO4)
5. concentrationconcentrated