HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Bromo-4-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Bromo-4-nitrobenzoic acid | HCID 313534 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Bromo-4-methoxybenzoic acid | HCID 14484713 | — |
Reaction Steps
2-Bromo-4-nitrobenzoic acid (3 g, 12.2 mmol) was reacted with sodium methoxide (6 g, 111 mmol) in dry DMSO (250 mL) at 80° C. After completion of reaction mixture was poured over crushed ice, acidified with 1:1 HCl and extracted with EtOAc (3×150 mL). The organic layer was concentrated to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884127B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-ccd2b7bdf5cc4372b3aaf2630c887c5f |
| Source note | uspto-grants-2011_02 |