Hexane → HCID 23024334, compound

HRID 1363464Notes

Reaction equation

HRID 1363464 reaction equation
[CH3:1]CCCCC.C[Si](C=[N+]=[N-])(C)C.[OH:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]([CH3:25])[C:17](=[O:26])[C:16]=1[I:27]>CO>[I:27][C:16]1[C:17](=[O:26])[N:18]([CH3:25])[C:19]2[C:24]([C:15]=1[O:14][CH3:1])=[CH:23][CH:22]=[CH:21][CH:20]=2

Participants

5

Reactant 3

HCID 8058HexaneHCID 167693TrimethylsilyldiazomethaneHCID 54687449HCID 54687449, compound

Product 1

HCID 23024334HCID 23024334, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1M hexane solution of trimethylsilyldiazomethane (10 ml) and methanol (5 ml) were added to 4-hydroxy-3-iodo-1-methyl-2(1H)-quinolinone (500 mg) and stirred at room temperature for one hour. The reaction solution was concentrated and purified with a silica gel chromatography (hexane-ethyl acetate) to obtain the title compound (479 mg).

Workup

  1. concentrationThe reaction solution was concentrated
  2. custompurified with a silica gel chromatography (hexane-ethyl acetate)

Sources & evidence

ORD record
ord-89c5a8a0bace47d1b5e5f1c6ad68a303
Source dataset
uspto-grants-2011_02
Patent number
US07884204B2

Reaction notes

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