1-Indanone, 4-bromo- → 4-Bromo-2,3-dihydro-1H-inden-1-amine

HRID 1363670Notes

Reaction equation

HRID 1363670 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=O.[BH3-]C#[N:14].[Na+]>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH2:14]

Participants

3

Reactant 2

HCID 987131-Indanone, 4-bromo-HCID 5003444Sodium cyanoborohydride

Product 1

HCID 431894514-Bromo-2,3-dihydro-1H-inden-1-amine

Procedure

The title amine was generated from 4-bromo-indan-1-one (5.00 g, 23.70 mmol), NaBH3CN (10.40 g, 165.50 mmol) and NH4OAc (54.80 g, 710.95 mmol) according to the protocols as outlined in general procedure B described above.

Sources & evidence

ORD record
ord-d7005cda0a1347afb9dda044969dda83
Source dataset
uspto-grants-2011_02
Patent number
US07884244B2

Reaction notes

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