Cyclohexanone → {2-[3-(2-Cyclohex-1-enyl-ethyl)-3-cyclohexyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid

HRID 1363696Notes

Reaction equation

HRID 1363696 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(CCN)CCCCC=1.C1(=O)CCCCC1>C(OC(=O)C)C>[C:23]1([CH2:22][CH2:21][N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]=1

Participants

5

Reactant 3

HCID 7967CyclohexanoneHCID 769382-(1-Cyclohexenyl)ethylamineHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acid

Product 1

HCID 16101130{2-[3-(2-Cyclohex-1-enyl-ethyl)-3-cyclohexyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid, from 2-(1-cyclohexenyl)-ethylamine, cyclohexanone and 2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-133fe83c7b1f4177a0b5be905227a33b
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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