Ethyl Propionate → HCID 16101136, compound

HRID 1363703Notes

Reaction equation

[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=CC=C[CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17](O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CC(C)CCN.C1(=O)CCCCC1.C([O:44][C:45](=[O:48])CC)C>>[CH:1]1([N:7]([CH2:21][CH2:22][CH:23]([CH3:24])[CH3:28])[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][CH2:17][C:45]([OH:48])=[O:44])=[CH:13][N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 4

HCID 7749Ethyl Propionate

HCID 7894Isoamylamine

HCID 7967Cyclohexanone

HCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acid

Product 1

HCID 16101136HCID 16101136, compound

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid, from 3-methylbutylamine, cyclohexanone and 2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester.

Workup

customPrepared

Sources & evidence

ORD record: ord-aa6cfcebfbe847aeaebee1d2678f3ef0
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07884210B2

Reaction notes

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