Benzenepropanal → {2-[3-(4-Methyl-cyclohexyl)-3-(3-phenyl-propyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid

HRID 1363715Notes

Reaction equation

HRID 1363715 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22]C2C=CC=CC=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:29]1([CH2:35]CC=O)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[CH3:39][C@H]1CC[C@H](N)CC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:39][CH:4]1[CH2:5][CH2:6][CH:1]([N:7]([CH2:21][CH2:22][CH2:35][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 7707BenzenepropanalHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461305HCID 178461305, compound

Product 1

HCID 57668212{2-[3-(4-Methyl-cyclohexyl)-3-(3-phenyl-propyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid using 3-phenylpropionaldehyde, trans-4-methyl-cyclohexylamine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3e2f4e34ae5c4de1b06fb9eac789f090
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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