Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668374, compound

HRID 1363819Notes

Reaction equation

HRID 1363819 reaction equation
C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)[C:8](=[O:19])[NH:9][C:10]2[S:11][CH:12]=[C:13](CC(O)=O)[N:14]=2)CCCC1.[CH:30]1([CH2:35][NH:36][C:37]2[CH:42]=[CH:41][C:40]([Br:43])=[CH:39][C:38]=2[F:44])[CH2:34][CH2:33][CH2:32][CH2:31]1.C([O:47][C:48](=[O:57])[CH2:49][S:50]C1SC(N)=NC=1)C>>[Br:43][C:40]1[CH:41]=[CH:42][C:37]([N:36]([CH2:35][CH:30]2[CH2:31][CH2:32][CH2:33][CH2:34]2)[C:8](=[O:19])[NH:9][C:10]2[S:11][C:12]([S:50][CH2:49][C:48]([OH:57])=[O:47])=[CH:13][N:14]=2)=[C:38]([F:44])[CH:39]=1

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 634192464-Bromo-N-(cyclopentylmethyl)-2-fluoroaniline

Product 1

HCID 57668374HCID 57668374, compound

Procedure

The title compound was prepared via {2-[3-(4-bromo-2-fluoro-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl esterin a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentylmethyl-(4-bromo-2-fluoro-phenyl)-amine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester

Sources & evidence

ORD record
ord-a030b6d63e1445528a128ff0548e9a1f
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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