HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,5-Bis(trifluoromethyl)phenol | HCID 67680 | — |
| Reactant | Ethyl 7-bromoheptanoate | HCID 122490 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate | HCID 86620562 | — |
Reaction Steps
Ethyl 7-bromoheptanoate and 3,5-bis(trifluoromethyl) phenol were added to dimethylformamide (DMF). The solution was added with potassium carbonate and stirred at room temperature. The solution was added with water and extracted twice with ethyl acetate. After the organic layer was washed three times with water and dried over anhydrous magnesium sulfate, the solvent was removed. The residue was purified by silica gel column chromatography to obtain ethyl 7-(3,5-bis (trifluoromethyl)phenoxy)heptanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07887835B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-e8e04a83780f4898b380de6ef251f5f6 |
| Source note | uspto-grants-2011_02 |