反应详情

Ethyl 7-bromoheptanoate and 3,5-bis(trifluoromethyl) phenol were added to dimethylformamide (DMF). The solution was added with potassium carbonate and stirred at room temperature. The solution was added with water and extracted twice with ethyl acetate. After the organic layer was washed three times with water and dried over anhydrous magnesium sulfate, the solvent was removed. The residue was purified by silica gel column chromatography to obtain ethyl 7-(3,5-bis (trifluoromethyl)phenoxy)heptanoate.

1. extractionextracted twice with ethyl acetate
2. washAfter the organic layer was washed three times with water
3. dry with materialdried over anhydrous magnesium sulfate
4. customthe solvent was removed
5. customThe residue was purified by silica gel column chromatography