HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Tryptophan → D-Alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Tryptophan | HCID 6305 | — |
| Reactant | D-Tryptophan | HCID 9060 | — |
| Reactant | Pyruvate | HCID 107735 | — |
| Product | D-Alanine | HCID 71080 | — |
| Product | 3-(1H-Indol-3-yl)-2-oxopropanoate | HCID 5460337 | — |
Reaction Steps
In a specific embodiment, L-tryptophan is converted to D-tryptophan using a tryptophan racemase. D-tryptophan then reacts with pyruvate via a broad specificity D-aminotransferase to produce indole-3-pyruvate and D-alanine. Indole-3-pyruvate then reacts with an R-specific aldolase and pyruvate to form R-α-keto acid monatin (R-MP). R-MP then reacts with a broad specificity D-aminotransferase and D-alanine to produce R,R monatin and pyruvate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07888081B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-b67ca4c44e1647458efeb30008d43f0c |
| Source note | uspto-grants-2011_02 |