Methyl 4-[(chlorocarbonyl)oxy]benzoate → HCID 57838898, compound

HRID 1363960Notes

Reaction equation

HRID 1363960 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=1)=[O:3].[CH2:15]([CH:18]1[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]1)[C:16]#[CH:17]>>[CH2:15]([CH:18]1[CH2:23][CH2:22][N:21]([C:2]([O:4][C:5]2[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=2)=[O:3])[CH2:20][CH2:19]1)[C:16]#[CH:17]

Participants

3

Reactant 2

HCID 854163Methyl 4-[(chlorocarbonyl)oxy]benzoateHCID 18187546Tert-butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate

Product 1

HCID 57838898HCID 57838898, compound

Procedure

4-(methoxycarbonyl)phenyl chloroformate (5.00 g, 23.3 mmol) was added to a solution of tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate (4.00 g, 17.9 mmol) according to general procedure 1. Yield=5.54 g, 99%. m/z MH+=302.02. HPLC rt=10.8 min.

Workup

  1. customHPLC rt=10.8 min.

Sources & evidence

ORD record
ord-2d2949ddcbc74e0ba7b223e2d86bcfb4
Source dataset
uspto-grants-2011_02
Patent number
US07888329B2

Reaction notes

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