Hydrochloric Acid → HCID 66958459, compound

HRID 1364038Notes

Reaction equation

HRID 1364038 reaction equation
[ClH:1].[CH:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]1[N:14]3[CH2:15][CH2:16][CH2:17][N:18](C(OC(C)(C)C)=O)[CH2:19][C:13]3=[N:12][C:5]=1[CH:6]=[N:7]2>O1CCOCC1.CO.C(OCC)C>[ClH:1].[CH:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]1[N:14]3[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][C:13]3=[N:12][C:5]=1[CH:6]=[N:7]2

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 66958550HCID 66958550, compound

Product 1

HCID 66958459HCID 66958459, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

Hydrogen chloride (100 mL of a 4 N solution in 1,4-dioxane) was added to a solution of tert-butyl 11,12-dihydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinoline-9(10H)-carboxylate (9.1 g, 27 mmol) in methanol (60 mL). The reaction was stirred overnight at ambient temperature and then diluted with diethyl ether. A precipitate was present and was isolated by filtration, washed sequentially with dichloromethane and diethyl ether, and dried under vacuum to provide 7.47 g of 9,10,11,12-tetrahydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinoline hydrochloride as a white solid.

Workup

  1. customwas isolated by filtration
  2. washwashed sequentially with dichloromethane and diethyl ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-3edca19f7cba48e0a88e7c2cabff9e8f
Source dataset
uspto-grants-2011_02
Patent number
US07888349B2

Reaction notes

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