Hydrochloric Acid → HCID 66958457, compound

HRID 1364068Notes

Reaction equation

HRID 1364068 reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]3[N:22]4[CH2:23][CH2:24][CH2:25][N:26](C(OC(C)(C)C)=O)[CH2:27][C:21]4=[N:20][C:15]=3[CH:16]=[N:17]2)=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.ClCCl.C(OCC)C>O1CCOCC1>[CH2:2]([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]3[N:22]4[CH2:23][CH2:24][CH2:25][NH:26][CH2:27][C:21]4=[N:20][C:15]=3[CH:16]=[N:17]2)=[CH:12][CH:11]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 66958691HCID 66958691, compound

Product 1

HCID 66958457HCID 66958457, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Hydrogen chloride (25 mL of a 4 N solution in 1,4-dioxane) was added to a solution of tert-butyl 3-benzyloxy-11,12-dihydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinoline-9(10H)-carboxylate in a 1:1 mixture of dichloromethane and diethyl ether (50 mL). The reaction was stirred overnight at ambient temperature; a precipitate formed. The precipitate was harvested via filtration and dried under reduce pressure to provide 9.66 g of 3-benzyloxy-9,10,11,12-tetrahydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinoline.

Workup

  1. customa precipitate formed
  2. filtrationThe precipitate was harvested via filtration
  3. customdried

Sources & evidence

ORD record
ord-9436a1f02640449d8f9ec834531825d1
Source dataset
uspto-grants-2011_02
Patent number
US07888349B2

Reaction notes

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