Bromine → HCID 66932810, compound

HRID 1364089Notes

Reaction equation

HRID 1364089 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][C:13](=[O:15])[CH2:12][C:11](=[O:16])[CH2:10]2)=[CH:5][CH:4]=1.[Br:17]Br>CC(O)=O>[Br:17][CH:12]1[C:11](=[O:16])[CH2:10][CH:9]([C:6]2[CH:5]=[CH:4][C:3]([S:2][CH3:1])=[CH:8][CH:7]=2)[CH2:14][C:13]1=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 99916325-[4-(Methylsulfanyl)phenyl]cyclohexane-1,3-dione

Product 1

HCID 66932810HCID 66932810, compoundYield 71.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a stirred solution of 5-[4-(methylthio)phenyl]cyclohexane-1,3-dione (1.08 g, 4.6 mmol) in AcOH (10 mL) at r.t. was added bromine (0.74 g, 0.23 mL, 4.6 mmol) dropwise. The reaction was then carried out according to Method A to give the title compound (1.03 g, 70%) as a white solid. LCMS (ES+) 314.9 (M+H)+.

Sources & evidence

ORD record
ord-ecad9787450c49a2a8948594fe3e352c
Source dataset
uspto-grants-2011_02
Patent number
US07888344B2

Reaction notes

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