反应详情

6-(Phenylmethyl)-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine (may be prepared as described in Description 5) (5.52 g, 24.29 mmol) was dissolved in ethanol (70 ml) under argon and 2M hydrochloric acid (12.2 ml, 24.4 mmol) added, followed by 50% wet 10% palladium on carbon catalyst (1 g). The mixture was stirred under an atmosphere of hydrogen for 18 hours. The catalyst was filtered and the filtrate evaporated to give the title compound (D6). MS (ES+) m/e [M+H]+

1. filtrationThe catalyst was filtered
2. customthe filtrate evaporated