Hydrochloric Acid → HCID 178478417, compound

HRID 1364112Notes

Reaction equation

HRID 1364112 reaction equation
C1(C[N:8]2[CH2:14][CH2:13][C:12]3=[CH:15][NH:16][N:17]=[C:11]3[CH2:10][CH2:9]2)C=CC=CC=1.[ClH:18]>C(O)C.[Pd]>[ClH:18].[N:17]1[NH:16][CH:15]=[C:12]2[CH2:13][CH2:14][NH:8][CH2:9][CH2:10][C:11]=12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178420305HCID 178420305, compound

Product 1

HCID 178478417HCID 178478417, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6-(Phenylmethyl)-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine (may be prepared as described in Description 5) (5.52 g, 24.29 mmol) was dissolved in ethanol (70 ml) under argon and 2M hydrochloric acid (12.2 ml, 24.4 mmol) added, followed by 50% wet 10% palladium on carbon catalyst (1 g). The mixture was stirred under an atmosphere of hydrogen for 18 hours. The catalyst was filtered and the filtrate evaporated to give the title compound (D6). MS (ES+) m/e [M+H]+

Workup

  1. filtrationThe catalyst was filtered
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-3e30dd022f3644f1b96f40591380e4e0
Source dataset
uspto-grants-2011_02
Patent number
US07888347B2

Reaction notes

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