Lithium → HCID 28824098, compound

HRID 1364181Notes

Reaction equation

HRID 1364181 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[C:15](=[O:16])[CH2:14][N:13]([CH3:17])[C:12]2=[O:18])[CH:5]=1.[Li]>O1CCCC1.O>[CH3:17][N:13]1[CH2:14][C:15](=[O:16])[N:11]([CH2:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:19])=[O:2])[C:12]1=[O:18]

Participants

4

Reactant 2

HCID 3028194LithiumHCID 66939757HCID 66939757, compound

Product 1

HCID 28824098HCID 28824098, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

To 3-(3-Methyl-2,5-dioxo-imidazolidin-1-ylmethyl)benzoic acid methyl ester (100 mg, 0.381 mmol) in THF/water (2/1, 2 mL) is added lithium hydroxyde monohydrate (24 mg, 0.572 mmol) and the reaction is stirred at rt during 16 h before quenching with water and ethylacetate. The separated aqueous phase is acidified to pH 2 with an aqueous 1N HCl solution, extracted with ethylacetate and the organic phase is dried and evaporated to give the title compound.

Workup

  1. custombefore quenching with water and ethylacetate
  2. extractionextracted with ethylacetate
  3. customthe organic phase is dried
  4. customevaporated

Sources & evidence

ORD record
ord-0e9da9ce810048da96e6a33d670e133d
Source dataset
uspto-grants-2011_02
Patent number
US07888351B2

Reaction notes

Loading…