Lithium → HCID 28824098, compound

Participants

Reaction Steps

To 3-(3-Methyl-2,5-dioxo-imidazolidin-1-ylmethyl)benzoic acid methyl ester (100 mg, 0.381 mmol) in THF/water (2/1, 2 mL) is added lithium hydroxyde monohydrate (24 mg, 0.572 mmol) and the reaction is stirred at rt during 16 h before quenching with water and ethylacetate. The separated aqueous phase is acidified to pH 2 with an aqueous 1N HCl solution, extracted with ethylacetate and the organic phase is dried and evaporated to give the title compound.

Provenance & Evidence