Methanol → Methyl (chlorosulfonyl)acetate

HRID 1364183Notes

Reaction equation

HRID 1364183 reaction equation
[Cl:1][S:2](Cl)(=[O:4])=[O:3].C[OH:7].[CH2:8]([O:10][CH2:11]C)[CH3:9]>>[CH3:11][O:10][C:8](=[O:7])[CH2:9][S:2]([Cl:1])(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 887MethanolHCID 3283Diethyl EtherHCID 24648Sulfuryl chloride

Product 1

HCID 11435213Methyl (chlorosulfonyl)acetate

Conditions

Temperature
0 °C

Procedure

To chlorosulfonyl chloride (3.34 g, 17.9 mmol) in diethyl ether (30 mL) is added at 0° C. methanol (800 μL, 19.7 mmol). The resulting mixture is stirred at 0° C. during 1 h and the solvent is evaporated to give the title compound.

Workup

  1. customthe solvent is evaporated

Sources & evidence

ORD record
ord-9a3b2141b7284048848ae638abe8f55e
Source dataset
uspto-grants-2011_02
Patent number
US07888351B2

Reaction notes

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