反应详情

To Chlorosulfonic acid (30 mL) is added 3,4-Dihydro-2H-isoquinolin-1-one (5 g, 34 mmol) at 0° C. After stirring at rt during 1 h, the mixture is heated at 50° C. during 16 h, then it is poured carefully into an ice bath and stirred at 0° C. during 30 min. The precipitate is filtered and dried in oven at 60° C. to give the title compound.

1. temperaturethe mixture is heated at 50° C. during 16 h
2. additionit is poured carefully into an ice bath
3. stirringstirred at 0° C. during 30 min
4. filtrationThe precipitate is filtered
5. customdried in oven at 60° C.