Chlorosulfonic acid → 1-Oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

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Reaction Steps

To Chlorosulfonic acid (30 mL) is added 3,4-Dihydro-2H-isoquinolin-1-one (5 g, 34 mmol) at 0° C. After stirring at rt during 1 h, the mixture is heated at 50° C. during 16 h, then it is poured carefully into an ice bath and stirred at 0° C. during 30 min. The precipitate is filtered and dried in oven at 60° C. to give the title compound.

Provenance & Evidence