2-Methoxy-1-phenylethanone → 3587-84-6

HRID 1364481Notes

Reaction equation

HRID 1364481 reaction equation
[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[CH3:1][O:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5]

Participants

4

Reactant 2

HCID 776982-Methoxy-1-phenylethanoneHCID 4311764Sodium borohydride

Product 1

HCID 5722943587-84-6Yield 78.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 2-methoxy-1-phenylethanone (1.0 g, 6.66 mmol) in ethanol was added sodium borohydride (0.28 g, 7.32 mmol). The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was quenched with sat. ammonium chloride solution, concentrated. Extracted with ethyl acetate, washed with brine, dried, and concentrated to yield 0.8 g of 2-methoxy-1-phenylethanol.

Workup

  1. customThe reaction mixture was quenched with sat. ammonium chloride solution
  2. concentrationconcentrated
  3. extractionExtracted with ethyl acetate
  4. washwashed with brine
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-6e2bde9bd215416492fcfa59e9a45d5b
Source dataset
uspto-grants-2011_02
Patent number
US07888366B2

Reaction notes

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