Iodoethane → HCID 15605225, compound

HRID 1364503Notes

Reaction equation

HRID 1364503 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[C:14]([CH3:17])[C@:13]([CH2:19][CH:20]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=4)[OH:21])([CH3:18])[CH2:12][C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1.I[CH2:29][CH3:30]>>[CH2:29]([O:21][CH:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)[CH2:19][C@:13]1([CH3:18])[C:14]([CH3:17])=[CH:15][C:16]2[N:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[N:9]=[CH:10][C:11]=2[CH2:12]1)[CH3:30]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 15605172HCID 15605172, compound

Product 1

HCID 15605225HCID 15605225, compound

Procedure

Using a procedure analogous to Example 35, the diastereomer mixture of the alcohols from Examples 75 and 76 (53 mg, 0.146 mmol) was reacted with iodoethane to give Example 77 as a 1:2 mixture of two diastereomers (20 mg, 35%).

Workup

  1. customto give Example 77
  2. additionas a 1:2 mixture of two diastereomers (20 mg, 35%)

Sources & evidence

ORD record
ord-9e878fd13b9d4f9192f51102cbe106ef
Source dataset
uspto-grants-2011_02
Patent number
US07888381B2

Reaction notes

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