2-Aminothiazole → HCID 87204934, compound

HRID 1364507Notes

Reaction equation

HRID 1364507 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[C:14]([CH3:17])[C@:13]([CH2:19][CH2:20][C:21]([NH:23][C:24]4[S:25][CH:26]=N[N:28]=4)=[O:22])([CH3:18])[CH2:12][C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1.N[C:30]1SC=NN=1.NC1SC=CN=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[C:14]([CH3:17])[C@:13]([CH2:19][CH2:20][C:21]([NH:23][C:24]4[S:25][CH:26]=[CH:30][N:28]=4)=[O:22])([CH3:18])[CH2:12][C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 21552-AminothiazoleHCID 199091,3,4-Thiadiazol-2-amineHCID 66919391HCID 66919391, compound

Product 1

HCID 87204934HCID 87204934, compound

Procedure

The title compound was prepared in a manner analogous to the preparation of the title compound of Example 171, replacing and 2-amino-1,3,4-thiadiazole with 2-aminothiazole. MS found: (M+H)+=397. 1H NMR (400 MHz, chloroform-D) δ ppm 1.20 (s, 3 H) 1.79-1.90 (m, 2 H) 1.91 (s, 3 H) 2.53-2.68 (m, 3 H) 2.79 (d, J=16.00 Hz, 1 H) 6.23 (s, 1 H) 7.06 (d, J=4.07 Hz, 1 H) 7.17 (t, J=8.65 Hz, 2 H) 7.39-7.50 (m, 4 H).

Sources & evidence

ORD record
ord-644720aa5bb64b93ac3708290042b1d2
Source dataset
uspto-grants-2011_02
Patent number
US07888381B2

Reaction notes

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